Experimental appraisal of factors involved in provision of donor livers.
نویسندگان
چکیده
The results of a series of porcine orthotopic liver homotransplants have shown that hepatic damage is related almost entirely to the period of warm ischaemia following death. Low flow perfusion with modified plasma would seem to be a satisfactory method of preserving cadaveric livers for at least six hours.In man it would appear possible to use cadaver livers derived from patients who had or had not been treated with artificial ventilation during life, provided the period of warm ischaemia is not longer than 25 to 30 minutes.
منابع مشابه
Gene Expression Profile in Liver Transplantation and the Influence of Gene Dysregulation Occurring in Deceased Donor Grafts
Background: Brain dead patients are the main source of organs for transplants. Brain death causes changes in peripheral organs. We define modifications of gene expression in specific pathways occurring in donor livers and their influence on gene expression profile of livers after transplant. Methods: We compared gene expression profile of both deceased donor livers and transplanted livers to ge...
متن کاملEstablishment Background and Factors Affecting the Success of Telemedicine Provision
Introduction: Today, access to healthcare is considered a major indicator of community health. Telemedicine technology is an opportunity to increase access and improve the quality of healthcare in a country's development of a healthcare system. The establishment of a telemedicine system and the provision of healthcare in this way require a proper infrastructure, and multiple fa...
متن کاملبررسی اثر مصرف دوز‌های پایین الکل بر کبد جنین موش صحرایی- مطالعه‌ی بافت‌شناسی
Background and Objective: Alcohol is a teratogenic agent for humans and can easily pass through the placenta. Low doses of alcohol are commonly found in alcoholic drinks, therefore the purpose of this study was to investigate the histological changes of fetal rat livers influenced by low doses of alcohol consumption. Materials and Methods: In this experimental study, pregnant female rats wer...
متن کاملMetabolic preconditioning of donor organs: defatting fatty livers by normothermic perfusion ex vivo.
Fatty liver is a significant risk factor for liver transplantation, and accounts for nearly half of the livers rejected from the donor pool. We hypothesized that metabolic preconditioning via ex vivo perfusion of the liver graft can reduce fat content and increase post-transplant survival to an acceptable range. We describe a perfusate medium containing agents that promote the defatting of hepa...
متن کاملDendritic Cells in Transplant Tolerance
Dendritic cells (DCs) are a heterogeneous family of professional APCs involved in priming adaptive immune responses. Donor DCs (direct pathway of allorecognition) and recipient DCs presenting processed donor major histocompatibility complex (MHC) as peptides (indirect pathway of allorecognition) participate actively in graft rejection by stimulating recipient T cell responses following organ tr...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- British medical journal
دوره 1 5640 شماره
صفحات -
تاریخ انتشار 1969